20 years of revenue, earnings, cash-flow and balance-sheet history from public filings.
Septerna, Inc. Common Stock (SEPN) operates in the BIOTECHNOLOGY industry and is headquartered in South San Francisco, United States with about 123 employees. Its market capitalization is roughly $2 billion. In the fiscal year ended 2025-12-31, SEPN reported $46M in revenue and ($49M) in net income.
Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases.
Interactive charts & full statements → Open the SEPN valuation workbench →
| Income statement | TTM → 2026-06-30 | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|---|
| Total Revenue | $99M | $46M | $1M | $0M | $0M |
| Gross Profit | $98M | $46M | $1M | $0M | — |
| Gross Margin % | 99.6% | 100.0% | 100.0% | 100.0% | — |
| Operating Income (EBIT) | ($44M) | ($81M) | ($81M) | $2M | ($28M) |
| Operating Margin % | -44.0% | -175.8% | -7518.4% | 1374.2% | — |
| Net Income | ($24M) | ($49M) | ($72M) | $4M | ($28M) |
| Net Margin % | -24.5% | -106.4% | -6678.9% | 2768.2% | — |
| EBITDA | ($40M) | ($47M) | ($71M) | ($45M) | ($27M) |
| Earnings Per Share (EPS) | $-0.55 | $-1.10 | $-1.93 | $0.21 | $-1.42 |
| Shares Outstanding (M) | 45M | 44M | 37M | 19M | 19M |
USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).
| Quarterly income statement | 2026-06-30 | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 |
|---|---|---|---|---|---|---|---|---|
| Total Revenue | $27M | $27M | $24M | $21M | $0M | $0M | $0M | $0M |
| Gross Profit | $27M | $26M | $24M | $21M | $0M | $0M | $0M | $0M |
| Gross Margin % | 100.0% | 98.4% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
| Operating Income (EBIT) | ($17M) | ($13M) | ($16M) | $3M | ($29M) | ($26M) | ($25M) | ($23M) |
| Operating Margin % | -62.9% | -50.1% | -66.4% | 12.2% | -24351.3% | -11831.1% | -11659.4% | -12812.5% |
| Net Income | ($13M) | ($9M) | ($11M) | $8M | ($25M) | ($21M) | ($21M) | ($21M) |
| Net Margin % | -48.7% | -32.6% | -44.5% | 38.0% | -20872.3% | -9806.4% | -9749.1% | -11660.8% |
| EBITDA | ($12M) | ($8M) | ($10M) | ($9M) | ($24M) | ($21M) | ($20M) | ($20M) |
| Earnings Per Share (EPS) | $-0.29 | $-0.19 | $-0.24 | $0.18 | $-0.56 | $-0.49 | $-0.64 | $-0.49 |
| Shares Outstanding (M) | 45M | 45M | 44M | 46M | 44M | 44M | 32M | 42M |
USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).
| Cash flow | TTM → 2026-06-30 | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|---|
| Cash from Operations (CFO) | $106M | $110M | ($67M) | ($39M) | ($23M) |
| Capital Expenditures (CapEx) | $1M | $1M | $2M | $3M | $1M |
| Free Cash Flow (FCF) | $105M | $110M | ($70M) | ($42M) | ($25M) |
| FCF Margin % | 106.3% | 238.7% | -6471.9% | -27550.3% | — |
USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).
| Quarterly cash flow | 2026-06-30 | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 |
|---|---|---|---|---|---|---|---|---|
| Cash from Operations (CFO) | ($22M) | ($26M) | ($15M) | $169M | ($20M) | ($23M) | ($21M) | ($17M) |
| Capital Expenditures (CapEx) | $0M | $1M | $0M | $0M | $0M | $0M | $1M | $1M |
| Free Cash Flow (FCF) | ($22M) | ($26M) | ($15M) | $169M | ($20M) | ($24M) | ($22M) | ($17M) |
| FCF Margin % | -82.9% | -99.8% | -62.4% | 785.3% | -17096.6% | -10833.3% | -10174.5% | -9881.8% |
USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).
| Balance sheet | 2026-06-30 | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|---|
| Total Assets | $567M | $596M | $457M | $131M | $36M |
| Cash & Cash Equivalents | $85M | $121M | $238M | $88M | $31M |
| Total Liabilities | $180M | $214M | $37M | $169M | $80M |
| Total Debt (Short + Long-Term) | $2M | $2M | $2M | $0M | $1M |
| Total Shareholders' Equity | $387M | $382M | $420M | ($38M) | ($44M) |
USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).
Quarterly statements, profitability ratios, price history, insider activity and institutional holders are in the interactive SEPN viewer.
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