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Upstream Bio, Inc. (UPB) Financial History

4 years of revenue, earnings, cash-flow and balance-sheet history from public filings.

Healthcare · Biotechnology · DATA UPDATED 2026-07-10

Upstream Bio, Inc. (UPB) operates in the Biotechnology industry and is headquartered in Waltham, United States with about 75 employees. Its market capitalization is roughly $425 million. In the fiscal year ended 2025-12-31, UPB reported $3M in revenue and ($143M) in net income.

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders.

Interactive charts & full statements → Open the UPB valuation workbench →

UPB Revenue & Earnings History — Annual Income Statement

Income statement2025-12-312024-12-312023-12-312022-12-31
Total Revenue$3M$2M$2M$1M
Operating Income (EBIT)($160M)($78M)($40M)($24M)
Net Income($143M)($63M)($20M)($24M)

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

UPB Quarterly Revenue & Earnings — Last 8 Quarters

Quarterly income statement2026-03-312025-12-312025-09-302025-06-302025-03-312024-12-31
Total Revenue$1M$1M$1M$1M$1M
Operating Income (EBIT)($44M)($46M)($38M)($44M)($32M)
Net Income($41M)($42M)($34M)($40M)($27M)

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

UPB Free Cash Flow History

UPB Balance Sheet History

Balance sheet2025-12-312024-12-312023-12-312022-12-31
Total Assets$354M$482M$117M$18M
Total Liabilities$14M$12M$240M$125M

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

Quarterly statements, profitability ratios, price history, insider activity and institutional holders are in the interactive UPB viewer.

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