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Protagonist Therapeutics Inc (PTGX) Financial History

20 years of revenue, earnings, cash-flow and balance-sheet history from public filings.

HEALTHCARE · BIOTECHNOLOGY · DATA UPDATED 2026-09-19

Protagonist Therapeutics Inc (PTGX) operates in the BIOTECHNOLOGY industry and is headquartered in Newark, United States with about 141 employees. Its market capitalization is roughly $9 billion. In the fiscal year ended 2025-12-31, PTGX reported $46M in revenue and ($130M) in net income.

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States.

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PTGX Revenue & Earnings History — Annual Income Statement

Income statementTTM → 2026-06-302025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Total Revenue$282M$46M$434M$60M$27M$27M$29M$0M$31M$20M$0M$0M$0M
Gross Profit$45M$434M$60M$27M$27M$29M$0M$31M$20M$0M$0M$0M
Gross Margin %97.3%100.0%100.0%100.0%100.0%100.0%100.0%100.0%100.0%
Operating Income (EBIT)$59M($158M)$253M($94M)($131M)($126M)($65M)($81M)($42M)($38M)($33M)($15M)($9M)
Operating Margin %20.9%-343.6%58.2%-156.1%-494.2%-460.0%-225.4%-34857.6%-136.7%-188.9%
Net Income$84M($130M)$275M($79M)($123M)($126M)($66M)($77M)($39M)($37M)($37M)($15M)($11M)
Net Margin %29.8%-282.8%63.3%-131.6%-464.3%-458.9%-231.1%-33414.3%-125.9%-184.2%
EBITDA($128M)$280M($76M)($128M)($123M)($64M)($77M)($42M)($37M)($32M)($15M)($9M)
Earnings Per Share (EPS)$1.02$-2.05$4.23$-1.39$-2.52$-2.71$-1.92$-2.98$-1.74$-2.09$-5.72$-2.52$-1.88
Shares Outstanding (M)64M65M57M49M46M34M26M22M18M7M6M6M

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

PTGX Quarterly Revenue & Earnings — Last 8 Quarters

Quarterly income statement2026-06-302026-03-312025-12-312025-09-302025-06-302025-03-312024-12-312024-09-302024-06-30
Total Revenue$214M$56M$7M$5M$6M$28M$171M$5M$4M
Gross Profit$56M$7M$5M$6M$28M$171M$5M$4M
Gross Margin %99.3%100.0%100.0%100.0%100.0%100.0%100.0%100.0%
Operating Income (EBIT)$159M($4M)($50M)($46M)($42M)($19M)$127M($41M)($39M)
Operating Margin %74.3%-6.5%-677.1%-985.2%-758.0%-68.2%74.3%-886.7%-931.0%
Net Income$163M$4M($44M)($39M)($35M)($12M)$132M($33M)($31M)
Net Margin %76.2%6.7%-596.8%-834.9%-627.0%-41.1%77.2%-710.4%-734.7%
EBITDA$3M($43M)($39M)($34M)($11M)$134M($33M)($30M)
Earnings Per Share (EPS)$2.29$0.05$-0.70$-0.62$-0.55$-0.19$1.98$-0.54$-0.50
Shares Outstanding (M)70M64M64M64M63M66M62M61M

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

PTGX Free Cash Flow History

Cash flowTTM → 2026-06-302025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Cash from Operations (CFO)$131M$58M$184M($70M)($108M)($108M)($72M)($42M)($50M)$4M($30M)($14M)($8M)
Capital Expenditures (CapEx)$1M$2M$1M$1M$1M$1M$0M$1M$0M$1M$0M$0M$0M
Free Cash Flow (FCF)$130M$56M$183M($71M)($109M)($109M)($73M)($42M)($50M)$3M($30M)($15M)($8M)
FCF Margin %46.1%121.9%42.1%-118.1%-409.8%-398.3%-254.8%-18395.7%-163.1%16.0%

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

PTGX Quarterly Free Cash Flow — Last 8 Quarters

Quarterly cash flow2026-06-302026-03-312025-12-312025-09-302025-06-302025-03-312024-12-312024-09-302024-06-30
Cash from Operations (CFO)$219M($49M)($37M)($2M)($29M)$125M($29M)($28M)$269M
Capital Expenditures (CapEx)$0M$0M$1M$0M$1M$1M$0M$1M$0M
Free Cash Flow (FCF)$219M($49M)($38M)($2M)($30M)$125M($29M)($29M)$269M
FCF Margin %102.3%-87.2%-516.6%-43.0%-533.6%440.7%-17.3%-612.6%6445.7%

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

PTGX Balance Sheet History

Balance sheet2026-06-302025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Total Assets$886M$670M$745M$358M$248M$348M$324M$155M$139M$164M$94M$15M$10M
Cash & Cash Equivalents$420M$128M$97M$187M$126M$124M$117M$33M$82M$106M$21M$4M$9M
Total Liabilities$44M$55M$69M$21M$32M$48M$45M$75M$27M$43M$6M$5M$2M
Total Debt (Short + Long-Term)$2M$1M$1M$3M$2M$1M$11M$1M$0M$0M$2M$0M
Total Shareholders' Equity$842M$615M$675M$337M$216M$300M$280M$80M($140M)($102M)($65M)$10M$8M

USD; $M / $B as marked. Newest period first. Source: public company filings (via Yahoo Finance aggregation).

Quarterly statements, profitability ratios, price history, insider activity and institutional holders are in the interactive PTGX viewer.

PTGX Metric Deep Dives

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